Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice

Vanessa SalazarBrett W. JaggerJuthathip MongkolsapayaKatherine E. BurgomasterWanwisa DejnirattisaiEmma S. WinklerEstefania FernandezChristopher A. NelsonDaved H. FremontTheodore C. PiersonJames E. CroweGavin R. ScreatonMichael S. DiamondVanderbilt University Medical CenterWashington University School of Medicine in St. LouisNational Institute of Allergy and Infectious DiseasesFaculty of Medicine, Siriraj Hospital, Mahidol UniversityNuffield Department of Clinical Medicine2020-01-272020-01-272019-02-05Cell Reports. Vol.26, No.6 (2019), 1585-1597.e4221112472-s2.0-85060452019https://repository.li.mahidol.ac.th/handle/123456789/50260© 2019 The Author(s) Salazar et al. show that SPOV, the flavivirus most closely related to ZIKV, infects mice when type I interferon signaling is blocked. SPOV causes ankle swelling and infection in the foot, which is more typical of alphaviruses. Human antibodies from ZIKV or DENV subjects protect against lethal SPOV challenge.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyDengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in MiceArticleSCOPUS10.1016/j.celrep.2019.01.052