Teerachai PunirunDarunee SoorukramChutima KuhakarnVichai ReutrakulManat PohmakotrMahidol University2018-11-092018-11-092014-01-01European Journal of Organic Chemistry. Vol.2014, No.19 (2014), 4162-4169109906901434193X2-s2.0-84903376187https://repository.li.mahidol.ac.th/handle/123456789/33638Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Mahidol UniversityChemistryArticleSCOPUS10.1002/ejoc.201402162