T. LOAKPRADITR. LOCKWOODMahidol University2018-03-222018-03-221977-01-01British Journal of Pharmacology. Vol.59, No.1 (1977), 135-14014765381000711882-s2.0-0017365208https://repository.li.mahidol.ac.th/handle/123456789/10337Cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. Isoprenaline (0.2 μg kg −1 min −1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. Oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non‐selectively. Para‐oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on heart rate and free fatty acids selectively. H 35/25 ((1‐(4‐methylphenyl)‐2‐isopropyl aminopropanol) hydrochloride, 3 mg/kg) antagonized the effects of isoprenaline on blood pressure, glucose and lactate selectively. It is concluded that metabolic adrenoceptors are differentiated into subtypes similar to those mediating cardiostimulation and vasodilatation. 1977 British Pharmacological SocietyMahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1111/j.1476-5381.1977.tb06987.x