Establishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2

Wasinee WongkummoolWarun ManeepitasutPirut Tong-ngamAmornrat TangprasittipapThongperm MunkongdeeChanikarn BoonchuaySaovaros SvastiNarisorn KitiyanantKittiphong PaiboonsukwongSuthat FucharoenAlisa TubsuwanMahidol University2018-12-212019-03-142018-12-212019-03-142017-04-01Stem Cell Research. Vol.20, (2017), 80-8318767753187350612-s2.0-85015405232https://repository.li.mahidol.ac.th/handle/20.500.14594/41876© 2017 The Authors The thalassemias are a group of genetic disorders characterized by a deficiency in the synthesis of globin chains. In this study the MUi009-A human induced pluripotent stem cell line was successfully generated from peripheral blood CD34 + haematopoietic progenitors of a 32 year old male who had coinherited a homozygous β°-thalassemia mutation at codon 41/42 (-TCTT) and a heterozygous α-thalassemia 4.2 deletion. The MUi009-A cell line exhibited embryonic stem cell characteristics with consistent pluripotency marker expression and the capability of differentiating into the three germ layers. The cell line may provide a tool for drug testing and gene therapy studies.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyEstablishment of MUi009 – A human induced pluripotent stem cells from a 32 year old male with homozygous β°-thalassemia coinherited with heterozygous α-thalassemia 2ArticleSCOPUS10.1016/j.scr.2017.02.012