Juengwongsa C.Charoenchaitrakool M.Charoenthai N.Puttipipatkhachorn S.Mahidol University2024-06-222024-06-222024-01-01Pharmaceutical Sciences Asia Vol.51 No.2 (2024) , 94-10525868195https://repository.li.mahidol.ac.th/handle/20.500.14594/98908The gas anti-solvent (GAS) process utilizing compressed carbon dioxide as an anti-solvent was applied to prepare coprecipitated particles between ketoconazole (KET), a poorly water-soluble drug substance, and nicotinamide (NIC), a water-soluble carrier. KET-NIC solid dispersion was also prepared by solvent evaporation and compared with the coprecipitated particles obtained from GAS process. DSC results indicated that KET formed eutectic with NIC at a weight ratio of 7:3. The results showed that the KET-NIC coprecipitated particles prepared by the GAS process, at an initial weight ratio of 1:1.5 in ethanolic solution, had suitable particle morphology and exhibited a remarkably higher dissolution than solid dispersion, physical mixture, and unprocessed KET. The formation of a simple eutectic mixture between KET and NIC in the coprecipitates prepared by both processes was confirmed by DSC, FTIR spectroscopy and powder X-ray diffraction. The enhanced dissolution of the GAS coprecipitated particles might be attributed to the eutectic formation, the improved wettability and hydrophilic microenvironment by the water-soluble carrier, the lower crystallinity, and the smaller size of the drug crystals.Pharmacology, Toxicology and PharmaceuticsMedicineArticleSCOPUS10.29090/psa.2024.02.24.14912-s2.0-8519605336025868470