Surin MuangmanMontri ThippornwongRutaiwan TohtongMahidol University2018-06-212018-06-212005-01-01In Vivo. Vol.19, No.1 (2005), 265-2680258851X2-s2.0-16244374976https://repository.li.mahidol.ac.th/handle/20.500.14594/16388A new approach to cancer therapy in recent years has been to target the metastatic process. The anti-metastatic potential of curcusone B, a diterpene isolated from Jatropha curcas Linn. (Euphorbiaceae), a herbal plant that has been used in traditional folk medicine in many tropical countries, was investigated against 4 human cancer cell lines. Treatment with non-cytotoxic doses of curcusone B resulted in a strong reduction of in vitro invasion, motility and secretion of matrix-metalloproteinases (MMP) of the cancer cells, whereas the ability to adhere to a Matrigel-coated surface was variably sensitive to curcusone B treatment. Curcusone B, thus, effectively suppresses the metastatic processes at doses that are non-toxic to cells, which may be of therapeutic benefit for the treatment of metastatic cancers.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS