Phaopraphat K.Sirijatuphat R.Mahidol University2025-04-302025-04-302025-06-01Medical Mycology Case Reports Vol.48 (2025)22117539https://repository.li.mahidol.ac.th/handle/123456789/109875Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed Cryptococcus neoformans in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.MedicineImmunology and MicrobiologyArticleSCOPUS10.1016/j.mmcr.2025.1007032-s2.0-105003133426