Novel roles of soxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant

Aekkapol MahavihakanontNisanart CharoenlapPoommaree NamchaiwWarawan EiamphungpornSorayut ChattrakarnPaiboon VattanaviboonSkorn MongkolsukChulabhorn Research InstituteEnvironmental HealthMahidol UniversityCenter of Excellence on Environmental Health2018-06-112018-06-112012-01-01Journal of Bacteriology. Vol.194, No.2 (2012), 209-21710985530002191932-s2.0-84855891357https://repository.li.mahidol.ac.th/handle/123456789/13864In Xanthomonas campestris pv. campestris, SoxR likely functions as a sensor of redox-cycling drugs and as a transcriptional regulator. Oxidized SoxR binds directly to its target site and activates the expression of xcc0300, a gene that has protective roles against the toxicity of redox-cycling compounds. In addition, SoxR acts as a noninducible repressor of its own expression. X. campestris pv. campestris requires SoxR both for protection against redox-cycling drugs and for full virulence on a host plant. The X. campestris model of the gene regulation and physiological roles of SoxR represents a novel variant of existing bacterial SoxR models. © 2012, American Society for Microbiology.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyNovel roles of soxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plantArticleSCOPUS10.1128/JB.05603-11