S. MartellaM. RietjensV. LohsiriwatR. LazzariA. VavassoriB. A. JereczekV. LazzatiM. C. LeonardiJ. Y. PetitIstituto Europeo di OncologiaMahidol UniversityUniversita degli Studi di Milano2018-09-242018-09-242010-12-23ecancermedicalscience. Vol.4, No.1 (2010)175466052-s2.0-80054741797https://repository.li.mahidol.ac.th/handle/20.500.14594/28571Background: Radiotherapy can cause adverse skin reactions over the course of their treatment. Currently, management is based on several tropical products although there is no gold-standard approach to prevention and management of radiation toxicity. Method: We report our experience of vitamin E acetate in the treatment of radiation dermatitis in breast cancer patients who experienced grade 4 side effects (according to Radiation Therapy Oncology Group criteria). Results: Clinical management consisted of oral antibiotics and local application of vitamin E acetate and local escarectomy. All of the patients achieved complete re-epithelialization within 40 days. Conclusion: Skin ulceration and necrosis post-radiation may interrupt oncological treatment in breast cancer patients. In acute radiodermatitis with skin necrosis, we propose the use of oral antibiotics together with escarectomy and the application of vitamin E acetate to facilitate the healing process in order to minimize the interruption to the oncological treatment. © the authors; licensee ecancermedicalscience.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.3332/ecancer.2010.190