Sakda Arj-OngAmmarin ThakkinstianMark McEvoyJohn AttiaFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol UniversityUniversity of Newcastle, Australia2018-09-242018-09-242010-08-01Pediatrics International. Vol.52, No.4 (2010), 527-5321442200X132880672-s2.0-77955785918https://repository.li.mahidol.ac.th/handle/20.500.14594/29578Background: There have been genetic studies assessing the association between tumor necrosis factor (TNF)-α- 308 and Kawasaki disease (KD) but the results have been conflicting due to lack of power. Therefore, a systematic review and meta-analysis was conducted to increase the power for identifying the association between the TNF-α- 308 polymorphism and KD. Method: Studies were identified from MEDLINE and EMBASE databases and were included if the subjects were children and the frequencies between TNF - 308 and KD were reported. Data were pooled using a random effect model if heterogeneity between studies was present. Results: Thirteen studies were identified however only six studies were included. The pooled prevalence of minor A allele was 5.2% (95% confidence interval [CI]: 0.1%-9.5%). Gene effect was assessed using per-allele and per-genotype approaches. The pooled odds ratio of G versus A with the random effect model was 1.13 (95%CI: 0.34-3.27). The genotype effects for GG versus GA+AA was estimated and the pooled odds ratio was 1.08 (95%CI: 0.42-2.92). Conclusion: This review suggests a trend of association between the TNF-α-308 G-allele and KD. However, the gene effects are heterogeneous and assessing sources of heterogeneity are limited. An updated meta-analysis is needed if more studies are published. © 2010 Japan Pediatric Society.Mahidol UniversityMedicineReviewSCOPUS10.1111/j.1442-200X.2010.03105.x