Li J.Xu F.Dai Y.Zhang J.Shi Y.Lai D.Sriboonvorakul N.Hu J.Mahidol University2023-06-182023-06-182022-12-01Polymers Vol.14 No.24 (2022)https://repository.li.mahidol.ac.th/handle/20.500.14594/84137To overcome the low water solubility and low bioavailability of curcumin (CUR), multiple delivery strategies have been proposed. Among these, cyclodextrin-based carriers have been widely used for the encapsulation and delivery of CUR. Cyclodextrins (CDs), as natural oligosaccharides, have been well known for their biodegradability, biocompatibility, non-toxicity, and internal hydrophobic and external hydrophilic structural features. This paper summarizes the recently reported CD-based carriers for encapsulating CUR. Particularly, the polymerization properties of CD self-assembly to enhance the encapsulation of CUR are discussed. In addition, the current progress on stimuli-responsive CD carriers for controlled release of CUR is described, which laid an important foundation for the development of CUR-based precision therapy in clinical practice. In conclusion, this review may provide ideas for the future development of a CD-based encapsulant for CUR.ChemistryReviewSCOPUS10.3390/polym142454212-s2.0-8514460159720734360