Canan G. NebigilChristiane MoogStéphan VagnerNadia Benkirane-JesselDuncan R. SmithLaurent DésaubryUniversite Paris-SaclayUniversité de StrasbourgInstitut CurieMahidol UniversityLes Hôpitaux Universitaires de StrasbourgInserm2020-08-252020-08-252020-10-01European Journal of Medicinal Chemistry. Vol.203, (2020)17683254022352342-s2.0-85088007294https://repository.li.mahidol.ac.th/handle/123456789/57806© 2020 Elsevier Masson SAS Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Mahidol UniversityChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.ejmech.2020.112653