Pharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumonia

Taniya PaiboonvongWichit NosoongnoenKorbtham SathirakulViratch TangsujaritvijitJaipak KaemapairojPramote TragulpiankitPreecha MontakantikulFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityMahidol University2020-01-272020-01-272019-01-01Antimicrobial Agents and Chemotherapy. Vol.63, No.10 (2019)10986596006648042-s2.0-85072588748https://repository.li.mahidol.ac.th/handle/20.500.14594/52172Copyright © 2019 American Society for Microbiology. All Rights Reserved. Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC0 – 8) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.)Mahidol UniversityMedicinePharmacokinetics and penetration of sitafloxacin into alveolar epithelial lining fluid in critically ill Thai patients with pneumoniaArticleSCOPUS10.1128/AAC.00800-19