S. VejbaesyaT. H. EiermannP. SuthipinititharmC. BanchaH. A.F. StephensK. LuangtrakoolD. ChandanayingyongMahidol UniversityUniversitatsklinikum Hamburg-Eppendorf und Medizinische Fakultat2018-07-042018-07-041998-01-01Tissue Antigens. Vol.52, No.4 (1998), 389-392000128152-s2.0-0031696149https://repository.li.mahidol.ac.th/handle/20.500.14594/18329The HLA class I and class II alleles in 67 patients with type I psoriasis vulgaris, 23 patients with type II psoriasis vulgaris and 140 healthy individuals were analyzed. The frequencies of HLA-A2, -B46, -B57 and DQB1*0303 were significantly increased in type I psoriasis compared to the controls (Pc < 0.05). Molecular analysis of HLA-A2 alleles showed an increase in HLA-A*0207 and a decrease in HLA-A*0203 in type I psoriasis. HLA-DQB1*0301 was significantly decreased in type I psoriasis compared to the normal controls (Pc < 0.05). No association of any alleles with type II psoriasis was observed. This data demonstrated two susceptible haplotypes: HLA-A1-B57-DRB1*0701-DQA1*0201-DQB1*0303 (AH57.1) and HLA-A2-B46-DRB1 *0901-DQA1*0301-DQB1*0303 (AH46.1) for type I psoriasis in the Thai population. Besides, the haplotype AH46.1 was also associated with type II psoriasis.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyMedicineArticleSCOPUS10.1111/j.1399-0039.1998.tb03061.x