Patompong UngprasertKarn WijarnpreechaWasin AhujaIttikorn SpanuchartCharat ThongprayoonMayo ClinicUniversity of Hawaii at Manoa John A. Burns School of MedicineMahidol UniversityChiang Mai University2018-11-232018-11-232015-11-01Hepatology Research. Vol.45, No.11 (2015), 1055-10611872034X138663462-s2.0-84988223680https://repository.li.mahidol.ac.th/handle/123456789/36275© 2015 The Japan Society of Hepatology. Aim: To investigate the association between primary biliary cirrhosis (PBC) and risk of coronary artery disease (CAD). Methods: We conducted a systematic review and meta-analysis of published observational studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratios with 95% confidence intervals (CI) comparing CAD risk in patients with PBC versus non-PBC controls. Pooled risk ratios and 95% confidence intervals were combined using a random-effect model and generic inverse variance of DerSimonian and Laird methods. Result: Four studies with 3362 patients with PBC were identified and included in our data analysis. The pooled risk ratio of CAD in patients with PBC was 1.57 (95% CI, 1.21-2.06). The statistical heterogeneity was low with an I2of 38%. Conclusion: Our study demonstrated a statistically significant increased risk of CAD among patients with PBC.Mahidol UniversityMedicineArticleSCOPUS10.1111/hepr.12452