Weeranut ChantachaengLeena ChularojanamontriKanokvalai KulthananKowit JongjarearnprasertNuruemon DhanaMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2018-05-032018-05-032011-09-26Asian Pacific Journal of Allergy and Immunology. Vol.29, No.3 (2011), 284-289222886940125877X2-s2.0-80053008561https://repository.li.mahidol.ac.th/handle/20.500.14594/11991Background: Sulfonamides are divided into two main groups which are sulfonamide antibiotics and sulfonamide non-antibiotics. The wide use of sulfonamide antibiotics leads to increasing incidence of sulfonamide cutaneous reactions. Objective: The purpose of this study is to explore the cutaneous manifestations induced by sulfonamide antibiotics in a large number of Thai patients, including human immunodeficiency virus (HIV) and non-HIV infected individuals. The second purpose is to determine the risk factors for development of sulfonamide cutaneous reactions. Methods: We retrospectively studied 191 patients with sulfonamide antibiotics cutaneous reactions attending the adverse drug reaction center, Siriraj Hospital, Bangkok between 2006 and 2010. Results: Majority of the patients was female (59.7%).Maculopapular rash was the most common cutaneous manifestation (37.7%), followed by fixed drug eruption (22%), angioedema with or without urticaria (12.6%) and urticaria alone (12%). Among those with known HIV serology, maculopapular eruption occurred more frequently in the HIV positive group while fixed drug eruption occurred more frequently in HIV-negative group. Conclusion: From our study, there were no significant determination factors to develop serious drug reactions. However, the HIVpositive status and lower level of CD4 count had a tendency to increase risk of developing serious cutaneous reactions.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS