Ryu S.Y.Nam B.H.Kim M.H.Jang W.I.Sitathanee C.Linh T.D.Lee K.H.Lee W.M.Kim E.T.Kang S.B.Kim J.H.Park J.Y.Lee K.B.Cho C.H.Lou H.Kim Y.H.Kim Y.T.Lee Y.H.Wu X.Kim J.W.Park S.I.Jeon S.Thinh D.H.Kry S.F.Gaffney D.Small W.Wilailak S.Mahidol University2026-03-162026-03-162026-04-01ESMO Open Vol.11 No.4 (2026)https://repository.li.mahidol.ac.th/handle/123456789/115739Background: The standard treatment for locally advanced cervical cancer is cisplatin-based chemoradiotherapy; however, the optimal dose and dosing schedule of cisplatin remain debated. The aim of this study was to compare the clinical outcomes of weekly cisplatin at 40 mg/m² versus those of tri-weekly cisplatin at 75 mg/m² during radiation in patients with locally advanced cervical cancer. Patients and methods: In this prospective, randomized clinical trial, we enrolled 314 patients with stage IIB-IVA cervical cancer, randomly assigning them in a 1: 1 ratio into two arms. The weekly arm received a weekly dose of 40 mg/m² cisplatin for six cycles, whereas the tri-weekly arm received a tri-weekly dose of 75 mg/m² cisplatin for three cycles, both concurrently with radiotherapy. The primary endpoints included 3-year recurrence-free survival according to a superiority design, with P < 0.05 indicative of statistical significance. Overall survival, toxicity profiles, and quality of life (QOL) were also analyzed. Results: Chemotherapy delay was more frequent in the weekly arm than in the tri-weekly arm (P = 0.008). However, the 3-year recurrence-free survival rate between the two arms did not significantly differ (78.7% in the weekly arm, 84.1% in the tri-weekly arm; hazard ratio 0.71, 95% confidence interval 0.39-1.32, P = 0.28). The pattern of recurrence did not differ significantly between the two arms. Grade 3 and 4 hematological toxicities occurred less frequently in the tri-weekly arm (P < 0.001). Furthermore, the tri-weekly arm had better QOL scores across several domains compared with the weekly arm. Conclusion: In this study, tri-weekly cisplatin-based chemoradiotherapy was not statistically superior to a weekly schedule in terms of survival outcomes for patients with locally advanced cervical cancer. However, the tri-weekly regimen exhibited a more favorable toxicity profile and improved QOL compared with the weekly regimen. These results suggest tri-weekly cisplatin administration as a feasible alternative for chemoradiotherapy in cervical cancer.Biochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/j.esmoop.2026.1061022-s2.0-10503241904920597029