Puangwan Lapthanasupkulพวงวรรณ ลาภธนทรัพย์กุลSopee Poomsawatโสภี ภูมิสวัสดิ์Jira Chindasombatjaroenจิรา จินดาสมบัติเจริญMahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial PathologyMahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial Radiology2013-01-142016-12-082013-01-142016-12-082013-01-142012-03Lapthanasupkul P, Poomsawat S, Chindasombatjaroen J. Investigation of basement membrane proteins in a case of granular cell ameloblastoma. Int J Oral Sci. 2012 Mar;4(1):45-9.1674-2818 (printed)2049-3169 (electronic)https://repository.li.mahidol.ac.th/handle/20.500.14594/930Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.engAmeloblastomaCollagen type IVFibronenctinGranular cellLaminin 1Laminin 5Open Access articleResearch ArticlePubMed Central10.1038/ijos.2012.9