Santi Prasad BajgaiVilailak PrachyawarakornChulabhorn MahidolSomsak RuchirawatPrasat KittakoopCenter for Environmental Health Toxicology and Management of Chemicals (ETM)Chulabhorn Research InstituteMahidol University2018-05-032018-05-032011-11-01Phytochemistry. Vol.72, No.16 (2011), 2062-2067003194222-s2.0-80052960367https://repository.li.mahidol.ac.th/handle/123456789/11250Hybrid flavan-chalcones, desmosflavans A (1) and B (2), together with three known compounds, cardamonin (3), pinocembrin (4) and chrysin (5), were isolated from leaves of Desmos cochinchinensis. Cardamonin (3) and chrysin (5) exhibited potent antioxidant activity with 15.0 and 12.2 ORAC units. Desmosflavans A (1) and B (2), pinocembrin (4), and chrysin (5) were found to be inhibitors of aromatase with respective IC 50 values of 1.8, 3.3, 0.9, and 0.8 μM. Desmosflavan A (1) inhibited lipoxygenase with the IC 50 value of 4.4 μM. Desmosflavan A (1) exhibited cytotoxic activity with IC 50 values of 0.29-3.75 μg/mL, while desmosflavan B (2) showed IC 50 values of 1.71-27.0 μg/mL. © 2011 Elsevier Ltd. All rights reserved.Mahidol UniversityAgricultural and Biological SciencesBiochemistry, Genetics and Molecular BiologyArticleSCOPUS10.1016/j.phytochem.2011.07.002