Jiraporn UngwitayatornChanpen WiwatWeerasak SameePatcharawee NunthanavanitNarumol PhosrithongMahidol UniversitySrinakharinwirot UniversitySiam University2018-05-032018-05-032011-08-24Journal of Molecular Structure. Vol.1001, No.1-3 (2011), 152-161002228602-s2.0-79961032360https://repository.li.mahidol.ac.th/handle/123456789/11702Novel chromone derivatives with a benzopyran-4-one scaffold have been prepared by the one-pot cyclization reaction. The in vitro inhibitory activity of these new compounds towards HIV-1 protease have been evaluated using stop time HPLC method as the preliminary screening. The most potent compound, 7,8-dihydroxy-2-(3′-trifluoromethyl phenyl)-3-(3″- trifluoromethylbenzoyl)chromone (32), showed IC 50 = 0.34 μM. The molecular docking study supported results from experimental activity testing and also provided structure-activity relationship of this series. © 2011 Elsevier B.V. All rights reserved.Mahidol UniversityChemistryArticleSCOPUS10.1016/j.molstruc.2011.06.035