Duy Ba NgoThanyarat ChaibunLee Su YinBenchaporn LertanantawongWerasak SurareungchaiAsian Institute of Medicine, Science & TechnologyMahidol UniversityKing Mongkut s University of Technology Thonburi2020-12-282020-12-282020-01-01Analytical and Bioanalytical Chemistry. (2020)16182650161826422-s2.0-85096622413https://repository.li.mahidol.ac.th/handle/123456789/60409© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. The aim of this study was to develop a highly specific electrochemical DNA sensor using functionalized lead sulphide (PbS) quantum dots for hepatitis E virus genotype 3 (HEV3) DNA target detection. Functionalized-PbS quantum dots (QDs) were used as an electrochemical label for the detection of HEV3-DNA target by the technique of square wave anodic stripping voltammetry (SWASV). The functionalized-PbS quantum dots were characterized by UV-vis, FTIR, XRD, TEM and zeta potential techniques. As-prepared, functionalized-PbS quantum dots have an average size of 4.15 ± 1.35 nm. The detection platform exhibited LOD and LOQ values of 1.23 fM and 2.11 fM, respectively. HEV3-DNA target spiked serum is also reported. Graphical abstract[Figure not available: see fulltext.].Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1007/s00216-020-03061-1