Akkharaphong ThupyaiChaleena PimpasriSirilata YotphanMahidol University2019-08-232019-08-232018-01-01Organic and Biomolecular Chemistry. Vol.16, No.3 (2018), 424-432147705202-s2.0-85040903440https://repository.li.mahidol.ac.th/handle/20.500.14594/45275© 2018 The Royal Society of Chemistry. A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(i) acetate, the C-S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c7ob02860a