Prasit SuwannalertNasapon PovichitPranom PuchadapiromMutita JunkingMahidol UniversityDetox (Thailand) Co. Ltd.Youcando R and D Institute2018-06-112018-06-112012-01-01Tropical Journal of Pharmaceutical Research. Vol.11, No.1 (2012), 69-7415969827159659962-s2.0-84930473893https://repository.li.mahidol.ac.th/handle/123456789/15103Purpose: To determine the anti-aging activity and toxicity doses of phytooxyresveratrol extracted from Artocarpus lakoocha Roxb. Methods: Artocarpus lakoocha 100 g was extracted with 2 ml of 95% ethanol to obtain phytooxyresveratrol (POV). Total phenolic content, as well as free radical scavenging and anti-glycation activities of POV were characterized in order to assess its anti-aging properties. The models of DNA nicking and bacterial reverse mutation (Ames) were applied to the extract in order to determine its effective and toxic doses, respectively. Results: Phytooxyresveratrol (POV) exhibited antiaging activity. It also showed high levels of phenolic content, radical scavenging activity and anti-glycation. A POV concentration of 25 μg/ml promoted strong anti-DNA nicking. Furthermore, it was non-toxic at concentrations ranging from 5 - 100 μg/ml. Conclusion: In vitro, phytooxyresveratrol (POV) extracted from Artocarpus lakoocha exerted effective anti-aging activity at a concentration of 25 μg/ml. Thus, the substance should be further studied for possible formulation into pharmaceutical products. © Pharmacotherapy Group. All rights reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.4314/tjpr.v11i1.9