Porntep ChomcheonSuthep WiyakruttaNongluksna SriubolmasNattaya NgamrojanavanichDuangnate IsarangkulPrasat KittakoopChulalongkorn UniversityMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-06-212018-06-212005-07-01Journal of Natural Products. Vol.68, No.7 (2005), 1103-1105016338642-s2.0-23844439228https://repository.li.mahidol.ac.th/handle/123456789/163283-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 μM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1). © 2005 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np050036a