Nednapis TirawanchaiPreyanuj YamwongKlai Upsorn PongrapeepornAtip LikidlilidSompong Ong-AjyoothAnchalee AmornrattanaMahidol University2018-09-072018-09-072000-11-01Journal of the Medical Association of Thailand. Vol.83, No.SUPPL. 2 (2000)012522082-s2.0-0034328599https://repository.li.mahidol.ac.th/handle/123456789/26114Lipoprotein lipase (LPL) is a multifunctional protein, playing a major role in the hydrolysis of triglyceride-rich lipoproteins. It also affects the maturation of high density lipoprotein (HDL) and low density lipoprotein (LDL). A D9N substitution is a frequent mutation found in exon 2 of the LPL gene. It is due to a G → A transition causing a substitution of Asp by Asn at amino acid residue 9 of the protein. This mutation was screened for in 94 Thai primary dyslipidemic (46 hypercholesterolemic and 48 combined hyperlipidemic) subjects compared to 32 normal healthy subjects using PCR-RFLP. Such a mutation has not, yet, been detected in any of these Thai subjects.Mahidol UniversityMedicineArticleSCOPUS