Somdej KanokmedhakulKwanjai KanokmedhakulPitak NasomjaiSysavad LouangsysouphanhKasem SoytongMinoru IsobePalangpon KongsaereeSamran PrabpaiApichart SuksamrarnKhon Kaen UniversityNational University of LaosKing Mongkut's Institute of Technology LadkrabangNagoya UniversityMahidol UniversityRamkhamhaeng University2018-08-202018-08-202006-06-01Journal of Natural Products. Vol.69, No.6 (2006), 891-895016338642-s2.0-33746488150https://repository.li.mahidol.ac.th/handle/123456789/23036Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50values of 10.5, 16.7, 24.3, and 0.6 μg/mL, respectively. © 2006 American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np060051v