Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N. NewtonSteven WardBrian J. AngusWirongrong ChierakulArjen DondorpRonnatrai RuangveerayuthKamolrat SilamutPramote TeerapongYupin SuputtamongkolSornchai LooareesuwanNicholas J. WhiteMahidol UniversityChurchill HospitalLiverpool School of Tropical MedicineMae Sot General HospitalFaculty of Medicine, Siriraj Hospital, Mahidol University2018-08-202018-08-202006-02-01Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.100, No.2 (2006), 184-186003592032-s2.0-29744436385https://repository.li.mahidol.ac.th/handle/123456789/23368A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. © 2005 Royal Society of Tropical Medicine Hygiene. Published by Elsevier Ltd. All rights reserved.Mahidol UniversityImmunology and MicrobiologyMedicineEarly treatment failure in severe malaria resulting from abnormally low plasma quinine concentrationsArticleSCOPUS10.1016/j.trstmh.2005.01.008