Monthira ChowichianPrapun AanpreungAnanya PongpaibulSirirat CharuvanijMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-282019-08-282018-01-01Paediatrics and International Child Health. (2018)20469055204690472-s2.0-85053309338https://repository.li.mahidol.ac.th/handle/20.500.14594/47063© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Systemic lupus erythematosus (SLE) is a multisystem, autoimmune inflammatory disease which can affect any organ, including the gastrointestinal tract. Lupus enteritis is one of the manifestations of gastrointestinal involvement in SLE patients. However, it is exceedingly rare that lupus enteritis is the sole initial presentation of SLE. A 12-year-old Thai girl who had had recurrent abdominal pain for 2 months with no other signs of SLE on initial presentation is described. A single-balloon enteroscopy demonstrated segmental erythema of the proximal and mid-jejunum. Histopathology demonstrated active enteritis and submucosal vasculitis. On the basis of evidence of intestinal vasculitis, autoimmune profiles were performed; the results supported the possibility of SLE. She subsequently developed leucopenia, lymphopenia and an oral ulcer, leading to a robust diagnosis of SLE. Her clinical condition improved dramatically with prednisolone. Even though lupus enteritis is rare, it can be the initial presentation of SLE. In young adolescent girls with recurrent abdominal pain, the possibility of lupus enteritis should be borne in mind.Mahidol UniversityMedicineSCOPUS10.1080/20469047.2018.1504430