Chirayu U. AuewarakulAmporn LeecharendkeatWanna ThongnoppakhunChanin LimwongseChintana TocharoentanapholMahidol University2018-08-202018-08-202006-05-01Haematologica. Vol.91, No.5 (2006), 675-678039060782-s2.0-33744465781https://repository.li.mahidol.ac.th/handle/20.500.14594/23750Point mutations of AML1 are uncommon and predominantly reported in a rare minimally differentiated acute myeloid leukemia (MO AML). Few data exist regarding the frequency of AML1 mutations in non-MO cases. We screened 284 consecutive adult Thai patients with de novo AML and found that 3.9% had AML1 mutations. The highest incidence occurred in M6. Six novel mutations were uniquely identified in non-MO cases. Sixty-four percent of the non-MO patients with AML1 mutations had coexisting genetic abnormalities including FLT3 mutation in 36%. Our study provides evidence to support the model of multiple co-operating events, which could also be critical in the development of leukemia in non-MO AML patients with mutated AML1. The prognostic significance of these novel mutations remains to be determined. ©2006 Ferrata Storti Foundation.Mahidol UniversityMedicineArticleSCOPUS