Sirikanya PhaikaewSomsak Suthutvoravutศิริกัญญา ไผ่แก้วสมศักดิ์ สุทัศน์วรวุฒิMahidol University. Faculty of Medicine Ramathibodi Hospital. Department of Obstetrics and Gynecology,2022-10-042022-10-042022-10-042012Ramathibodi Medical Journal. Vol. 35, No. 4 (Oct-Dec 2012), 314-3190125-3611 (Print)2651-0561 (Online)https://repository.li.mahidol.ac.th/handle/20.500.14594/79802Objective: To compare postpartum blood loss and side effects between parturients receiving intravenous oxytocin (WHO recommendation) with intravenous methylergometrine maleate (ergometrine) (Ramathibodi Hospital regimen) immediately after child birth. Methods: The prospective randomized study of 80 parturients assigned to receive either oxytocin or ergometrine in the third stage of labor. All parturient were managed during first stage and second stage of labor according to the regimen of active management of labor (AMOL). Outcome measures were the postpartum blood loss, duration of third stage of labor, side effects of drug, and complications of delivery. Chi-square and t-test were used for hypothesis testing at level = 0.05. Results: There was on significant difference in postpartum blood loss between the 2 groups. In ergometrine group, longer duration of third stage of labor was observed with more elevated systolic blood pressure and pulse rate than in oxytocin group more uterotonic drugs were added after devilry. Conclusion: Oxytocin and ergometrine administered immediately after birth showed no difference in postpartum blood loss.engMahidol UniversityPostpartum hemorrhageErgometrineOxytocinThird stage of laborOriginal ArticleDepartment of Obstetrics and Gynecology Faculty of Medicine Ramathibodi Hospital Mahidol University