W. TurakitwanakanB. PanichareonW. SukhumsirichartFaculty of Medicine, Siriraj Hospital, Mahidol UniversitySrinakharinwirot University2020-01-272020-01-272019-07-01Journal of the Medical Association of Thailand. Vol.102, No.7 (2019), 29-34012522082-s2.0-85070331913https://repository.li.mahidol.ac.th/handle/20.500.14594/51558© JOURNAL OF THE MEDICAL ASSOCIATION OF THAILAND| 2019. Background: Serotonin 5-HT4 receptor (HTR4) is involved in learning and memory process. The location of this gene is in schizophrenia-susceptible loci. Objective: The present study aimed to investigate the variation in HTR4 gene in association with schizophrenia in Thai population. Materials and Methods: A total of 75 schizophrenia patients and 170 normal controls volunteered in this study. DNAs were extracted from whole blood. The purified DNAs were amplified and genotyped by PCR using 3’-locked nucleic acid (LNA) modified SNP primers and by high resolution melting (HRM) analysis. The differences in genotype distribution between patients and controls were assessed by Chi-square test of the SPSS software version 11.5. Results: All studied SNPs were in Hardy-Weinberg equilibrium. Two SNPs, rs2277051 and rs2277049, showed significant association with schizophrenia (p = 0.001, and p = 0.015, respectively). The genotype C of rs2277051 and G of rs2277049 existed in schizophrenia more than in control. Conclusion: The authors found two SNPs in intronic region of serotonin 5-HT4 receptor gene, rs2277051 and rs2277049, that related to the susceptibility for schizophrenia in Thai population.Mahidol UniversityMedicineArticleSCOPUS