Patima PhainuphongVatcharin RukachaisirikulSaowanit SaithongSouwalak PhongpaichitKawitsara BowornwiriyapanChatchai MuanprasatChutima SrimaroengAcharaporn DuangjaiJariya SakayarojPrince of Songkla UniversityMahidol UniversityChiang Mai UniversityUniversity of PhayaoThailand National Center for Genetic Engineering and Biotechnology2018-12-112019-03-142018-12-112019-03-142016-06-24Journal of Natural Products. Vol.79, No.6 (2016), 1500-150715206025016338642-s2.0-84976319210https://repository.li.mahidol.ac.th/handle/20.500.14594/42997© 2016 The American Chemical Society and American Society of Pharmacognosy. Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC50value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC50value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC50value of 2.2 μM.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1021/acs.jnatprod.5b00961