Napadol SiritipArkom NongnuchThanate DajsakdiponCharat ThongprayoonWisit CheungprasitpornJackrapong BruminhentFaculty of Medicine Ramathibodi Hospital, Mahidol UniversityMayo ClinicUniversity of Mississippi Medical Center2022-08-042022-08-042021-03-01American Journal of the Medical Sciences. Vol.361, No.3 (2021), 352-35715382990000296292-s2.0-85097458525https://repository.li.mahidol.ac.th/handle/20.500.14594/78422Background: Multi-drug resistant organisms have been emerging among kidney transplant (KT) recipients with bloodstream infections (BSI). The investigation for epidemiology, risk factors and outcome of these infections following KT was initiated. Materials and Methods: A retrospective study of all adult KT recipients who developed a BSI within the first year after KT in 2016 at a single transplant center was conducted. The cumulative incidence of BSI was estimated with Kaplan-Meier methodology. Clinical characteristics and outcome were extracted. Risk factors were analyzed with Cox proportional hazards models. Results: Among 171 KT recipients, there were 26 (15.2%) episodes of BSI. Fifty-nine percent were men and the mean ± SD age was 43 ± 12 years. The cumulative incidence of BSIs was 10.1% at 1 month, 13.5% at 6 months, and 15.2% at 12 months. Gram-negative bacteria were responsible for 92% of BSIs, Escherichia coli was the most common pathogen (65%) followed by Klebsiella pneumoniae (11%). Among those, 71% were resistant to extended-spectrum cephalosporins. The genitourinary tracts were the predominant source of BSIs (85%). The second kidney transplantation (HR, 4.55; 95% CI, 1.24–16.79 [P = 0.02]) and receiving induction therapy (HR, 3.05; 95% CI, 1.15-8.10 [P < 0.03]) were associated with BSI in a multivariate analysis. One patient (4%) developed allograft rejection, allograft failure and death from septic shock. Conclusions: One out of six KT recipients could develop BSI from gram-negative bacteria within the first year after transplant, particularly in those that received the second transplantation or induction therapy.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.amjms.2020.10.011