S. P. WatcharanananA. ThakkinstianC. SrichunrasmeeW. ChuntratitaV. SumethkulMahidol University2018-11-092018-11-092014-01-01Transplantation Proceedings. Vol.46, No.2 (2014), 328-33118732623004113452-s2.0-84896479890https://repository.li.mahidol.ac.th/handle/20.500.14594/34505Background Data on the immunogenicity (IG) of the influenza vaccine among patients at high risk of influenza-related complication are limited. Methods We studied the antibody titer following a single dose of monovalent 2009 influenza A (H1N1) vaccine between groups of adult patients who were healthy, those with chronic renal failure (CRF), kidney transplant (KT) recipients, and human immunodeficiency virus (HIV)-infected patients. The IG (primary endpoints) was accessed at 4 weeks after vaccination. The secondary endpoint was safety of the vaccine. Results A total of 293 patients were studied. Patients' mean age was 41(standard deviation [SD], 13.3) years old. At baseline, mean age (P <.001), history of vaccination in a prior year (P <.001), and geometric mean titers (GMT; P <.001) significantly differed between each groups and the majority (70%) of participants had the hemagglutination inhibition titer <1:10. The IG of the vaccine was highest in the healthy group (71.4 %). The response rate among CRF, KT, and HIV groups was 42.4% (risk ratios [RR], 0.72; 95% confidence interval [CI], 0.5-1.02), 31.9% (RR, 0.51; 95% CI, 0.34-0.76), and 29.7% (RR, 0.42; 95% CI, 0.3-0.6), respectively. The vaccine was well-tolerated in all studied groups. Thirty (10.2%) patients experienced at least 1 adverse reaction but systemic reaction was uncommon (3.4%). Conclusions A single dose of monovalent 2009 influenza A (H1N1) vaccine result in poor IG among high-risk populations, including CRF, KT and HIV patients. © 2014 by Elsevier Inc. All rights reserved.Mahidol UniversityMedicineConference PaperSCOPUS10.1016/j.transproceed.2013.11.063