Nuttapol RittayamaiSivaporn HemvimonNitipatana ChierakulFaculty of Medicine, Siriraj Hospital, Mahidol University2020-01-272020-01-272019-06-01Journal of Critical Care. Vol.51, (2019), 133-13815578615088394412-s2.0-85061840580https://repository.li.mahidol.ac.th/handle/20.500.14594/51608© 2019 Purpose: Rapid shallow breathing index (RSBI) is a commonly used index for predicting the outcome of spontaneous breathing trial (SBT). Ultrasound is a non-invasive technique for assessing diaphragm activity and function. This study aimed to investigate changes in diaphragm activity during SBT, and to compare diaphragm function between patients with and without SBT success. Materials and methods: Forty-five patients undergoing SBT were enrolled. Thickening fraction of the diaphragm was assessed during tidal breathing (TFdi tidal ), and RSBI was measured during 30 min of SBT. Diaphragm function measured by maximum TFdi (TFdi max ) and diaphragmatic excursion (DE max ) was also evaluated. Results: TFdi tidal and RSBI significantly increased during SBT (TFdi tidal0 vs. TFdi tidal30 = 29.8 ± 13.8 vs. 37.4 ± 13.0%; p < .001, and RSBI 0 vs. RSBI 30 = 64.8 ± 25.9 vs.70.8 ± 29.1 breaths/min/L; p = .034). In SBT failure (n = 13), there was no significant difference in TFdi tidal compared to SBT success, except at the beginning of the trial (p = .043); however, RSBI significantly increased throughout SBT. No differences in TFdi max or DE max were observed between groups. Conclusions: Patient inspiratory efforts significantly increased during SBT. TFdi tidal measured by diaphragm ultrasound could not distinguish between patients with SBT success and failure. RSBI was significantly higher during SBT in patients with SBT failure.Mahidol UniversityMedicineArticleSCOPUS10.1016/j.jcrc.2019.02.016