W. ThamavitM. A. MooreSomsak RuchirawatN. ItoMahidol UniversityNagoya City University Medical School2018-08-102018-08-101992-01-31Cancer Letters. Vol.61, No.3 (1992), 229-232030438352-s2.0-0026603318https://repository.li.mahidol.ac.th/handle/20.500.14594/22260The effects of repeated praziquantel administration subsequent to dimethylnitrosamine (DMN) treatment of Syrian hamsters were investigated. The antihelminthic drug was given (200 mg/kg body wt. as a suspension in corn oil, by i.g. intubation) 11 times at 2 week intervals starting at week 4 after initial 20 mg/kg DMN i.p: injections at weeks 0 and 2. Sacrifice at week 28 revealed no differences in either hepatocellular or cholangiocellular lesion development between carcinogen-initiated groups with or without antihelminthic treatment. No lesions were observed in the praziquantel alone or untreated groups. The results thus indicate no promotion potential for praziquantel on nitrosamine-induced lesions in the hamster liver. © 1992.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1016/0304-3835(92)90292-4