Kwanjai KanokmedhakulSomdej KanokmedhakulRuchiruttikorn SuwannatraiKasem SoytongSamran PrabpaiPalangpon KongsaereeKhon Kaen UniversityKing Mongkut's Institute of Technology LadkrabangMahidol University2018-05-032018-05-032011-07-29Tetrahedron. Vol.67, No.30 (2011), 5461-546814645416004040202-s2.0-79959336246https://repository.li.mahidol.ac.th/handle/20.500.14594/11510Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tet.2011.05.066