Nipith CharoenngamArash ShirvaniMichael F. HolickFaculty of Medicine, Siriraj Hospital, Mahidol UniversityBoston Medical Center2020-01-272020-01-272019-12-01Current Opinion in Endocrinology, Diabetes and Obesity. Vol.26, No.6 (2019), 301-305175229781752296X2-s2.0-85074553607https://repository.li.mahidol.ac.th/handle/123456789/50011© 2019 Wolters Kluwer Health, Inc. All rights reserved. Purpose of reviewThe goal of this review is to give some perspective on the results and conclusions of three recent randomized controlled vitamin D intervention studies that have challenged the health benefit of vitamin D supplementation for reducing risk for cardiovascular disease, cancer, all-cause mortality and type 2 diabetes and improving bone health.Recent findingsVitamin D supplementation to adults who were vitamin D sufficient or insufficient did not reduce risk for developing cardiovascular disease, cancer, type 2 diabetes nor increases bone mineral density (BMD). Patients who were vitamin D deficient with cancer and received vitamin D reduced risk for mortality by 25% and prediabetic adults who were vitamin D deficient and received vitamin D reduced their risk of developing type 2 diabetes by 62%. Older adults receiving 4000 and 10000IUs of vitamin D3 daily for 3 years had reduced radial BMD but had no change in either total hip areal bone density or bone strength in the radius and tibia.SummaryCaution is needed when evaluating results and conclusions from randomized controlled trials that investigate health benefits of vitamin D; most studies suggest health benefits when vitamin D supplementation is provided to vitamin D deficient populations and little benefit when given to populations that are vitamin D sufficient/insufficient.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.1097/MED.0000000000000508