Michael D. EdsteinIseng D. LikaTan ChongsuphajaisiddhiArunee SabchareonH. Kyle WebsterArmed Forces Research Institute of Medical Sciences, ThailandMahidol University2018-08-102018-08-101991-01-01Therapeutic Drug Monitoring. Vol.13, No.2 (1991), 146-15115363694016343562-s2.0-0025851884https://repository.li.mahidol.ac.th/handle/20.500.14594/22217Two simple, precise, and selective high-performance liquid chromatographic methods are described for the simultaneous quantitation of me-floquine (MQ) plus pyrimethamine (PYR) or sulfadoxine (SDX) plus its principal metabolite SDX including internal standards were separated using ion-paired and ion-suppression chromatography. Total run times for the assays were 12 min. Intraassay and interassay precision of the methods expressed as the coefficients of variation were 9% in plasma for the four compounds. The extraction recovery averaged 98% for MQ, 97% for PYR, 96% for SDX, and 81% for Plasma concentrations of the four compounds in a pediatric patient after a single oral dose of Fansimef (MQ + SDX + PYR) were determined to demonstrate the clinical application of the methods. © 1991 Reven Press, Ltd., NewYork.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1097/00007691-199103000-00010