Monzr M. Al MalkiRichard JonesQing MaDean LeeYair ReisnerJeffrey S. MillerPeter LangSuradej HongengParameswaran HariSamuel StroberJianhua YuRichard MaziarzDomenico MavilioDenis Claude RoyChiara BoniniRichard E. ChamplinEphraim J. FuchsStefan O. CiureaHumanitas UniversityIRCCS San Raffaele Scientific InstituteStanford University School of MedicineUniversità degli Studi di MilanoUniversity of Minnesota Twin CitiesUniversitätsklinikum Tübingen Medizinische FakultätThe Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsWeizmann Institute of Science IsraelOregon Health and Science UniversityUniversity of Texas MD Anderson Cancer CenterMahidol UniversityMedical College of WisconsinHopital Maisonneuve-RosemontCity of Hope National Med CenterOhio State UniversityChildren's Hospital Columbus2019-08-282019-08-282018-05-01Biology of Blood and Marrow Transplantation. Vol.24, No.5 (2018), 895-90815236536108387912-s2.0-85041640816https://repository.li.mahidol.ac.th/handle/20.500.14594/46743© 2018 The American Society for Blood and Marrow Transplantation The resurgence of haploidentical stem cell transplantation (HaploSCT) over the last decade is one of the most important advances in the field of hematopoietic stem cell transplantation (HSCT). The modified platforms of T cell depletion either ex vivo (CD34 + cell selection, “megadoses” of purified CD34 + cells, or selective depletion of T cells) or newer platforms of in vivo depletion of T cells, with either post-transplantation high-dose cyclophosphamide or intensified immune suppression, have contributed to better outcomes, with survival similar to that in HLA-matched donor transplantation. Further efforts are underway to control viral reactivation using modified T cells, improve immunologic reconstitution, and decrease the relapse rate post-transplantation using donor-derived cellular therapy products, such as genetically modified donor lymphocytes and natural killer cells. Improvements in treatment-related mortality have allowed the extension of haploidentical donor transplants to patients with hemoglobinopathies, such as thalassemia and sickle cell disease, and the possible development of platforms for immunotherapy in solid tumors. Moreover, combining HSCT from a related donor with solid organ transplantation could allow early tapering of immunosuppression in recipients of solid organ transplants and hopefully prevent organ rejection in this setting. This symposium summarizes some of the most important recent advances in HaploSCT and provides a glimpse in the future of fast growing field.Mahidol UniversityMedicineConference PaperSCOPUS10.1016/j.bbmt.2018.01.008