Wilawan ThirapatarapongHilary F. ArmstrongByron M. ThomashowMatthew N. BartelsColumbia University Medical CenterMahidol University2018-10-192018-10-192013-03-01Respiratory Physiology and Neurobiology. Vol.186, No.1 (2013), 81-8618781519156990482-s2.0-84873255174https://repository.li.mahidol.ac.th/handle/20.500.14594/31356Impaired ventilation on cardiopulmonary exercise test (CPET) is seen in patients with chronic obstructive pulmonary disease (COPD). However, evaluation of the differences of abnormal gas exchange in COPD according to GOLD severity criteria is limited. A retrospective review was performed on all COPD patients referred for CPET at our center between 1998 and 2010. There were 548 patients compared according to GOLD severity. GOLD groups were significantly different from each other in regards to pressure of end-tidal carbon dioxide (PETCO2) with progressively higher PETCO2 with increasing GOLD severity. Ratio of minute ventilation to carbon dioxide production (V̇E/V̇CO2) and exercise capacity as measured by and V̇O2 % and work rate in watts% was inversely proportional to GOLD severity. Breathing reserve, minute ventilation, and tidal volume at peak exercise were significantly decreased with increasing disease severity between GOLD groups. We concluded that gas exchange is distinctive among different GOLD severity groups; specifically, GOLD 3 and 4 have a significantly higher PETCO2 and a significantly lower V̇E/V̇CO2 than GOLD 2. © 2013 Elsevier B.V.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineNeuroscienceArticleSCOPUS10.1016/j.resp.2012.12.013