Davor SolterMahidol UniversityMax Planck Institute of Immunobiology and Epigenetics2018-12-112019-03-142018-12-112019-03-142016-12-01Current Topics in Developmental Biology. Vol.117, (2016), 377-391007021532-s2.0-84955574680https://repository.li.mahidol.ac.th/handle/20.500.14594/42692© 2016 Elsevier Inc. Whether or not early mammalian development results from preformation or epigenesis remains an unresolved issue. Evidence for or against either is weak, inconclusive, and often misinterpreted. Yet, one can parsimoniously conceptualize formation of the mouse blastocyst as a series of random, stochastic events stemming from initial and sequential small asymmetries in egg, zygote, and cleavage stages. Differential compartmentalized gene expression does not lead but follows the morphogenesis and cell fate allocation in the mammalian blastocyst.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChapterSCOPUS10.1016/bs.ctdb.2015.11.006