Prasert SobhonSuchart UpathamChaitip WanichanonKledkaew Panyong2025-02-032025-02-03199120251991Thesis (M.Sc. (Anatomy))--Mahidol University, 1991https://repository.li.mahidol.ac.th/handle/20.500.14594/103306Anatomy (Mahidol University 1991)The histological and ultrastructural changes occurring in the liver and small intestine of mice were examined by light and transmission electron microscopy, following the oral administration of praziquantel at the dosages of 250 mg/kg/day for 5 and 10 days and a single dose of 1250 mg/kg/day. Reversible signs of injury were observed in liver cells, following praziquantel administration at the dose 250 mg/kg/day for 10 days. These changes were partial depolymerization of the cytoskeletal network, vesiculation and dilatation of RER, proliferation of SER, glycogen depletion and chromatin clumping. In contrast, more severe and irreversible changes in the liver cells were observed at a single oral dose of 1250 mg/kg/day, they consisted of the accumulation of lipid droplets, mitochondrial swelling, degeneration and clumping of chromatin and the presence of intranuclear inclusions. In comparison to the liver cells, the intestinal epithelial cells showed only mild degenerative changes consisting of decreased cytoplasmic density, dilatation of RER, swelling of mitochondria and presence of multivesicular bodies and mvelin - like figures. These changes occurred only in the epithelial cells covering the lower part of villi while those on the upper part remained intact.vii, 136 leaves : ill.application/pdfengผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้าIntestines -- drug effectsLiver -- drug effectsPraziquantel -- administration & dosageMaster ThesisMahidol University