Nopparat SuthprasertpornNirut SuwannaWipawan ThangniponKasetsart University, Kamphaeng Saen CampusMahidol University2020-01-272020-01-272019-01-01Drug and Chemical Toxicology. (2019)15256014014805452-s2.0-85072040450https://repository.li.mahidol.ac.th/handle/20.500.14594/50533© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Oxidative stress is implicated in pathogenesis of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. The study demonstrates diarylpropionitrile (DPN), an antioxidant selective agonist of estrogen receptor β, protected human neuroblastoma SH-SY5Y cells against H2O2-induced toxicity by attenuating production of reactive oxygen species, apoptosis, autophagy, NF-κB activation, MAPK p38, JNK and ERK 1/2 signaling pathways, and β-site amyloid precursor protein cleaving enzyme level, but, interestingly, stimulating Akt pathway. These findings indicate the important potential of DPN to ameliorate oxidative stress-associated damage in neurodegenerative disorders.Mahidol UniversityChemical EngineeringEnvironmental ScienceMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1080/01480545.2019.1658768