Kiangsungnoen J.Puwarawuttipanit W.Riangkam C.Rongrungruang Y.Mahidol University2025-03-232025-03-232025-01-01Siriraj Medical Journal Vol.77 No.3 (2025) , 209-219https://repository.li.mahidol.ac.th/handle/123456789/106768Objective: This study aimed to evaluate the effectiveness of a brain training program designed to enhance the cognitive function of sepsis survivors. Materials and Methods: We conducted a single-blind randomized controlled trial at a tertiary care hospital involving 67 participants aged over 18 years with participants randomly assigned to two groups, an experimental group (n=33) receiving the brain training program, and a control group (n=34) receiving standard care only. We measured cognitive function at three different time points: Baseline, Week 6, and Week 12, using the Thai Mental State Examination for testing and repeated measure ANOVA for statistical analysis. Results: The experimental group had a higher mean cognitive function score at Week 6 posttest than at pretest. At Week 12, the mean cognitive function score increased significantly compared with that at pretest (F = 442.279, p <.001) and the experimental group had a higher mean cognitive function score than the control group (F = 104.905, p <.001). Conclusion: The brain training program significantly increased the cognitive function levels of sepsis survivors in 6–12 weeks. The result of this study shows the benefits of a brain training program in increasing cognitive functions. Therefore, such a brain training program should be implemented among sepsis survivors to improve their cognitive functions.MedicineArticleSCOPUS10.33192/smj.v77i3.2721292-s2.0-8600078336022288082