Sujittra ChaisavaneeyakornJulie M. MooreLisa MirelCaroline OthoroJuliana OtienoSansanee C. ChaiyarojYa Ping ShiBernard L. NahlenAltaf A. LalVenkatachalam UdhayakumarNational Center for Infectious DiseasesThe University of GeorgiaMahidol UniversityKenya Medical Research InstituteNew Nyanza Provincial General HospitalOrganisation Mondiale de la SanteCenters for Disease Control and Prevention2018-07-242018-07-242003-07-01Clinical and Diagnostic Laboratory Immunology. Vol.10, No.4 (2003), 631-6361071412X2-s2.0-12444294421https://repository.li.mahidol.ac.th/handle/20.500.14594/20716Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β play an important role in modulating immune responses. To understand their importance in immunity to placental malaria (PM) and in human immunodeficiency virus (HIV)-PM coinfection, we investigated levels of these chemokines in the placental intervillous blood plasma (IVB plasma) and cord blood plasma of HIV-negative PM-negative, HIV-negative PM-positive, HIV-positive PM-negative, and HIV-positive PM-positive women. Compared to HIV-negative PM-negative women, the MIP-1β concentration in IVB plasma was significantly elevated in HIV-negative PM-positive women and HIV-positive PM-positive women, but it was unaltered in HIV-positive PM-negative women. Also, PM-infected women, irrespective of their HIV status, had significantly higher levels of MIP-1β than HIV-positive PM-negative women. The MIP-1α level was not altered in association with either infection. The IVB plasma levels of MIP-1α and MIP-1β positively correlated with the cord blood plasma levels of these chemokines. As with IVB plasma, only cord plasma from PM-infected mothers had significantly elevated levels of MIP-1β compared to PM-negative mothers, irrespective of their HIV infection status. MIP-1β and MIP-1α levels in PM-positive women were positively associated with parasite density and malaria pigment levels. Regardless of HIV serostatus, the IVB MIP-1β level was significantly lower in women with PM-associated anemia. In summary, an elevated level of MIP-1β was associated with PM. HIV infection did not significantly alter these two chemokine levels in IVB plasma.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyImmunology and MicrobiologyArticleSCOPUS10.1128/CDLI.10.4.631-636.2003