C-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisitene

S. EkthawatchaiS. KamchonwongpaisanP. KongsaereeB. TarnchompooY. ThebtaranonthY. YuthavongMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-09-072018-09-072001-12-20Journal of Medicinal Chemistry. Vol.44, No.26 (2001), 4688-4695002226232-s2.0-0035924213https://repository.li.mahidol.ac.th/handle/20.500.14594/26424Nucleophilic additions of lithium keto and ester enolates and mono- and bifunctional Grgnard reagents to artemisitene provided C-16-derived artemisinin monomers, dmers, trimers, and tetramers whose antimalarial and cytotoxic have been evaluated.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsC-16 artemisinin derivatives and their antimalarial and cytotoxic activities: Syntheses of artemisinin monomers, dimers, trimers, and tetramers by nucleophilic additions to artemisiteneArticleSCOPUS10.1021/jm0103007