Thitima LhinhatrakoolSamran PrabpaiPalangpon KongsaereeSomyote SutthivaiyakitRamkhamhaeng UniversityMahidol University2018-05-032018-05-032011-06-24Journal of Natural Products. Vol.74, No.6 (2011), 1386-139115206025016338642-s2.0-79959726526https://repository.li.mahidol.ac.th/handle/20.500.14594/11530Eight new sesquiterpene alkaloids (1 - 8) and four known sesquiterpene alkaloids (9 - 12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines. © 2011 The American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np200014k