J. P. SheppardK. L. TuckerW. J. DavisonR. StevensW. AekplakornH. B. BosworthA. BoveK. EarleM. GodwinB. B. GreenP. HebertC. HeneghanN. HillF. D.R. HobbsI. KantolaS. M. KerryA. LeivaD. J. MagidJ. MantK. L. MargolisB. McKinstryM. A. McLaughlinK. McNamaraS. OmboniO. OgedegbeG. ParatiJ. VarisW. J. VerberkB. J. WakefieldR. J. McManusCardiovascular Research Institute MaastrichtUniversity of CambridgeUniversity of EdinburghUniversity of OxfordTurun Yliopistollinen KeskussairaalaNYU Grossman School of MedicineQueen Mary, University of LondonMonash UniversityMemorial University of NewfoundlandDeakin UniversityKaiser PermanenteFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversity of Washington, SeattleVA Medical CenterLewis Katz School of MedicineHealthPartnersIcahn School of Medicine at Mount SinaiUniversity of Milano - BicoccaUniversity of East Anglia, Faculty of Medicine and Health SciencesSt George's Hospital, LondonUniversity of Colorado at DenverSechenov First Moscow State Medical UniversityDuke UniversityIRCCS Istituto Auxologico ItalianoPrimary Care Research Unit of MallorcaItalian Institute of Telemedicine2020-03-262020-03-262020-03-13American journal of hypertension. Vol.33, No.3 (2020), 243-251194172252-s2.0-85081945275https://repository.li.mahidol.ac.th/handle/20.500.14594/53724© The Author(s) 2019. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. BACKGROUND: Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS: A systematic review was conducted of articles published in Medline, Embase, and the Cochrane Library up to January 2018. Randomized controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested. Contributing studies were prospectively categorized by whether they examined a low/high-intensity co-intervention. Change in BP and likelihood of uncontrolled BP at 12 months were examined according to number and type of hypertension-related co-morbidity in a one-stage IPD meta-analysis. RESULTS: A total of 22 trials were eligible, 16 of which were able to provide IPD for the primary outcome, including 6,522 (89%) participants with follow-up data. Self-monitoring was associated with reduced clinic systolic BP compared to usual care at 12-month follow-up, regardless of the number of hypertension-related co-morbidities (-3.12 mm Hg, [95% confidence intervals -4.78, -1.46 mm Hg]; P value for interaction with number of morbidities = 0.260). Intense interventions were more effective than low-intensity interventions in patients with obesity (P < 0.001 for all outcomes), and possibly stroke (P < 0.004 for BP control outcome only), but this effect was not observed in patients with coronary heart disease, diabetes, or chronic kidney disease. CONCLUSIONS: Self-monitoring lowers BP regardless of the number of hypertension-related co-morbidities, but may only be effective in conditions such obesity or stroke when combined with high-intensity co-interventions.Mahidol UniversityMedicineArticleSCOPUS10.1093/ajh/hpz182