Thirayudh GlinsukonWisuda SuvitayawatSomphong SahaphongPawinee PiyachaturawatMahidol University2018-06-142018-06-141987-01-01Toxicology Letters. Vol.36, No.1 (1987), 95-103037842742-s2.0-0023132872https://repository.li.mahidol.ac.th/handle/20.500.14594/15473Effects of cytochalasin E on the secretion of H + and volume of gastric juice were investigated in gastric fistula rats. Direct exposure of the gastric mucosa to cytochalasin E (5-20 μg/ml) inhibited H + secretory rate in all of the pentagastrin-, histamine- as well as non-stimulated rats but it did not affect the secretory volume of gastric juice. The inhibitory action of cytochalasin E on H + secretion had a rapid onset and showed a dose-dependent pattern. The mechanism of inhibitory action was not related to its interaction with plasma membrane receptors or membrane enzyme, K + -stimulated ATPase. Interference with cellular energy production as well as alteration of microfilament function, which are essential for H + production and secretion respectively, are likely to be the bases of the cytochalasin inhibition. © 1987.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/0378-4274(87)90046-4